OUP user menu

Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides

Kathy Musa-Veloso, Malcolm Angus Binns, Alexandra Catherine Kocenas, Theresa Poon, Julie Ann Elliot, Harry Rice, Hilde Oppedal-Olsen, Hilary Lloyd, Shawna Lemke
DOI: http://dx.doi.org/10.1111/j.1753-4887.2010.00272.x 155-167 First published online: 1 March 2010

Abstract

The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200–500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve. The response variable was defined as percent change from baseline in fasting serum TG, adjusted for the placebo effect. A weighting factor equal to the product of each study's sample size and quality score was used. Using the equation of the dose-response curve, predicted reductions in fasting serum TG levels at the recommended long-chain omega-3 fatty acid intakes of 200–500 mg/day are 3.1 to 7.2%.

  • docosahexaenoic acid
  • eicosapentaenoic acid
  • fish oil
  • omega-3 fatty acids
  • triglycerides
View Full Text

Sign in

Log in through your institution

Sign in as a personal subscriber

Log in through your institution

Purchase a personal subscription