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Gestational vitamin D deficiency: long-term effects on the brain

Cathy W Levenson, Silvia M Figueirôa
DOI: http://dx.doi.org/10.1111/j.1753-4887.2008.00122.x 726-729 First published online: 1 December 2008


Gestational vitamin D deficiency causes permanent changes in the developing rat brain. Not only does it alter brain gene and protein expression, deficiency disrupts the balance between neuronal stem cell proliferation and programmed cell death in the offspring. These data are particularly relevant in light of new work showing a high prevalence of vitamin D deficiency in humans.

  • apoptosis
  • brain
  • stem cells
  • schizophrenia
  • VDR
  • vitamin D
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