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Biological activity of lycopene metabolites: implications for cancer prevention

Jonathan R Mein, Fuzhi Lian, Xiang-Dong Wang
DOI: http://dx.doi.org/10.1111/j.1753-4887.2008.00120.x 667-683 First published online: 1 December 2008

Abstract

While early studies focused on the potential roles in health and disease of provitamin A carotenoids, such as β-carotene, research over the past decade has provided a framework for our understanding of the functions of non-provitamin A carotenoids such as lycopene, especially in regards to its association with a reduced risk of a number of chronic diseases, including cancer. Recent data suggests that lycopene metabolites may possess specific biological activities on several important cellular signaling pathways and molecular targets. Carotenoid metabolites may have more important biological roles than their parent compounds in human health and disease. This notion has been reinforced by the observation of both beneficial and detrimental effects of carotenoid metabolites in cancer prevention.

  • biological activity
  • cancer prevention
  • lycopene metabolites
  • Abbreviations:

    ACR
    acyclo-retinoic acid
    ARE
    antioxidant response element
    CMO1
    beta-carotene 15,15′-oxygenase
    CMO2
    carotene-9′,10′-oxygenase
    Cx43
    connexin 43
    GJC
    Gap Junction Communication
    IGF
    insulin-like growth factor
    IGFBP
    insulin-like growth factor binding protein
    RAR
    retinoic acid receptor
    RARE
    retinoic acid response element
    RXR
    retinoid X receptor
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