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Influence of Dietary Fiber on Inflammatory Bowel Disease and Colon Cancer: Importance of Fermentation Pattern

Devin J. Rose , Mark T. DeMeo , Ali Keshavarzian , Bruce R. Hamaker
DOI: http://dx.doi.org/10.1111/j.1753-4887.2007.tb00282.x 51-62 First published online: 1 February 2007


The benefits of dietary fiber on inflammatory bowel disease may be related to the fermentative production of butyrate in the colon, which appears to decrease the inflammatory response. The benefits of dietary fiber against colon cancer may be related to both fermentative and non-fermentative processes, although poorly fermentable fibers appear more influential. Dietary fiber fermentation profiles are important in determining optimal fibers for colonic health, and may be a function of structure, processing conditions, and other food components. A greater understanding of the relationships between fermentation rate and dietary fiber structure would allow for development of dietary fibers for optimum colonic health.

  • butyrate
  • Crohn's disease
  • microbiota
  • short chain fatty-acids
  • ulcerative colitis

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