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Food Fortification with Folic Acid: Has the Other Shoe Dropped?

Noel W. Solomons MD
DOI: http://dx.doi.org/10.1111/j.1753-4887.2007.tb00276.x 512-515 First published online: 1 November 2007


Folic acid (FA) supplementation effectively reduces the rates of children born with neural tube defects (NTDs). Currently, 42 nations practice mandatory FA fortification to combat NTD. In addition to NTD, FA fortification may also have salutary effects on the incidence of orofacial cleft birth defects and have secondary benefits in reducing serum homocysteine concentrations and stroke mortality. However, a recent note of caution has been raised concerning a possible negative effect of mandatory FA fortification on the incidence of colorectal cancer.

  • food fortification
  • folic acid
  • colorectal cancer rates
  • North America

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