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Iron Transport across Biologic Membranes

Nancy C. Andrews M. D., Ph D, Mark D. Fleming D.Phil., M. D., Hiromi Gunshin Ph D
DOI: http://dx.doi.org/10.1111/j.1753-4887.1999.tb06934.x 114-123 First published online: 1 April 1999

Abstract

Iron is essential for life, but is toxic in excess. Nearly all organisms have therefore developed regulated mechanisms for efficient transport of iron into cells. This paper reviews the current understanding of iron transport, focusing on valuable lessons from studies of yeast iron transport and the discovery of the first mammalian transmembrane iron transporter.

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