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σ-Tocopherol: an Efficient Protector of Lipids against Nitric Oxide—initiated Peroxidative Damage

George Wolf
DOI: http://dx.doi.org/10.1111/j.1753-4887.1997.tb01566.x 376-378 First published online: 1 October 1997


Nitric oxide released by macrophages during inflammation reacts with active oxygen to form peroxynitrite. Peroxynitrite nitrates protein and peroxidizes lipids. σ-Tocopherol traps peroxynitrite and is more effective than α-tocopherol in protecting lipids against such peroxidation.

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